Relevant papers
- Nijjar, S., Maddison, D., Meigh, L., de Wolf, E., Rodgers, T., Cann, M.J., and Dale, N. (2021) Opposing modulation of Cx26 gap junctions and hemichannels by CO2. J Physiol 599, 103-118.
- Dale, N. (2021) CO2 sensing by connexin26 and its role in the control of breathing. Interface Focus 11, 20200029. 10.1098/rsfs.2020.0029.
- van de Wiel, J., Meigh, L., Bhandare, A., Cook, J., Nijjar, S., Huckstepp, R., and Dale, N.(2020) Connexin26 mediates CO2-dependent regulation of breathing via glial cells of the medulla oblongata. Communications Biology 3, 521.
- Hill, E., Dale, N., and Wall, M.J. (2020)
Hill, E., Dale, N., and Wall, M.J. (2020). Moderate changes in CO2 modulate the firing of neurons in the VTA and substantia nigra. iScience 101343.
- Cook, J., de Wolf, E. and Dale, N. (2019) Cx26 keratitis ichthyosis deafness syndrome mutations trigger alternative splicing of Cx26 to prevent expression and cause toxicity in vitro. Royal Society Open Science doi.org/10.1098/rsos.191128
- de Wolf, L., Cook, J. and Dale, N. (2017) Evolutionary adaptation of the sensitivity of connexin26 hemichannels to CO2. Proc Roy Soc B doi:10.1098/rspb.2016.2723.
- de Wolf, L., van de Wiel, J., Cook, J. and Dale, N. (2016) Altered CO2 sensitivity of connexin26 mutant hemichannels in vitro. Physiol Rep 4:e13038
- Meigh, L., Cook, D., Zhang, J. and Dale, N. (2015) Rational design of new NO and redox sensitivity into connexin26 hemichannels. Open Biology 5:140208.
- Meigh, L., Hussain, N., Mulkey, D.K. and Dale, N. (2014) Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2. eLife 3:e04249
- Meigh, L., Greenhalgh, S., Rodgers, T.L., Cann, M.J., Roper, D.I. and Dale, N. (2013) CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits. eLife 2:e01213
- Huckstepp, R.T.R and Dale, N. (2011) Redefining the components of central CO2 chemosensitivity -towards a better understanding of mechanism. J Physiol 589, 5561-5579.
- Huckstepp, R.T.R., id Bihi, R., Eason, R., Spyer, K.M., Dicke, N., Willecke, K., Marina, N., Gourine, A.V. and Dale, N. (2010) Connexin hemichannel-mediated CO2-dependent release of ATP in the medulla oblongata contributes to central respiratory chemosensitivity. J Physiol 588, 3901-3920.
- Huckstepp, R.T.R., Eason, R., Sachdev, A. and Dale, N. (2010) CO2-dependent opening of connexin 26 and related β connexins. J Physiol 588, 3921-3931.
- Gourine, A.V., Llaudet, E., Dale, N. & Spyer, K.M. (2005) ATP is mediator of chemosensory transduction in the central nervous system. Nature 436, 108-111.