The overall theme of our group is how neurons communicate with each other to achieve the desired neural function. Our work splits into two major areas: Neurophysiology and Technology development.
Our interests presently concentrate around the investigation of chemical signalling in the brain. One common theme is purinergic signalling by ATP and adenosine and its roles in several different functional contexts such as: centrally mediated chemosensitive reflexes involved in the control of breathing and arousal; signalling by hypothalamic tanycytes in the context of the control of body weight and food intake; homeostatic control of sleep; endogenous neuroprotective mechanisms in the brain; and during early development. Our work goes from structural biology of proteins through to study of function in physiological systems. We use a combination of electrophysiological, imaging and biosensing methods to study these problems.
We have an active program to provide novel analytical tools for neuroscience research. In particular we are developing microelectrode biosensors specific for a number of transmitters to enable better exploration of chemical signalling in the nervous system. We have concentrated on microelectrode biosensors for the purines and have formed the Warwick Biosensors Group to further this aim. We have also developed biosensors for other analytes (such as glutamate, lactate, D-serine, acetylcholine) and have developed a range of highly selective biosensors for clinical diagnostic purposes.
Banner illustration: puncta of Cx26 (red) on the surface of astrocytes (green) at the ventral surface of the medulla oblongata.